EPONA | Equine Regenerative Solutions by Vitti Labs

EPONA EQUINE MEDICINE

THE SCIENCE BEHIND StrideGUARD™

Built for the Forces Behind Every Stride

Every stride places changing demands on the equine joint. StrideGUARD™ is designed as a cohesive, viscoelastic matrix that cushions, distributes, and responds to applied force.

THE CHALLENGE

A horse's joints and tissues do more than move. They manage force.

During every stride, the joint must accommodate changing combinations of compression, shear, rotation, and impact. Those forces become more demanding with speed, collection, turning, uneven footing, fatigue, and repetitive work.

COMPRESSION

Load driven through the joint

SHEAR

Joint surfaces sliding across one another

ROTATION

Limb twisting through turns and uneven footing

REPETITIVE LOADING

Ride after ride, stride after stride

THE DESIGN

A Matrix Designed to Remain Cohesive

StrideGUARD™ contains an interconnected collagen network supporting a glycosaminoglycan-rich matrix. This cross-braced architecture is designed to resist rapid displacement and maintain structural continuity as force is applied.

STRUCTURAL PROOF

The Structure of StrideGUARD™ Seen Under Scanning Electron Microscopy

StrideGUARD™ contains an interconnected collagen network supporting a glycosaminoglycan-rich matrix. This cross-braced architecture is designed to resist rapid displacement and maintain structural continuity as force is applied.

photos of scans

WHAT YOU ARE LOOKING AT

  1. Overall interconnected network.
    Collagen fibers and ground substance occupying one continuous structure. Scale bar 80 µm.
  2. Surface architecture.
    The textured boundary where ground substance meets the fiber network.
  3. Fiber and matrix detail.
    Individual fibrils resolved within the surrounding amorphous material.
  4. High-magnification structure.
    Fine fibrillar organization at 2700×. Scale bar 50 µm.

WHY IT MATTERS

This architecture helps explain how StrideGUARD™ remains cohesive and distributes applied force through its structure.

Two Preserved Components, Two Distinct Jobs

StrideGUARD™ preserves the two primary structural components of native Wharton’s jelly: an interconnected collagen fiber network and a hydrated, glycosaminoglycan-rich ground substance.

Collagen Network

ROLE: STRUCTURAL FRAMEWORK

  • Creates an interconnected network
  • Supports cohesion
  • Reinforces structural stability
  • Distributes applied force
  • Contributes to elastic recovery

Glycosaminoglycan-Rich Matrix

ROLE: HYDRATED CUSHIONING ENVIRONMENT

  • Attracts and retains water
  • Responds under compression
  • Supports viscoelastic behavior
  • Accommodates changing loads
  • Complements the collagen framework

FUNCTIONAL PROOF

A Glycosaminoglycan-Rich Matrix

Glycosaminoglycans contribute to the hydrated behavior of StrideGUARD™ and its ability to deform and respond under compression.

GAG matrix chart

Why Glycosaminoglycans Matter

Hydration contributes to cushioning, compression response, and recovery as loading conditions change. GAGs bind water, helping the matrix retain its volume and integrity under loads.

How the Matrix Behaves Under Applied Force

Rheological testing characterizes how the StrideGUARD™ matrix responds across a range of shear rates and following high-shear stress.

Responds as Force Changes

Tested: Viscosity across a range of shear rates.

Result: StrideGUARD™ changed its flow behavior as increasing shear was applied.

Why it matters: The matrix adapts to provide realtime support as the horse moves rather than behaving like a rigid material.

Maintains a Cohesive Structure

Tested: Shear-thinning profile against synovial reference ranges.

Result: The profile is characteristic of native Wharton’s jelly-derived extracellular matrix.

Why it matters: The structure resists rapid separation or displacement while still moving with the joint.

StrideGUARD™ technology is tested under intense stress, so you can trust its support when you need it the most.

Stress Recovery Test

StrideGUARD demonstrates the ability to rapidly respond from elastic support (joint and tissue lubrication) to visco support (cushioning) in less than 30 seconds even after intense activity such as abrupt start-stop motion, high-speed movement, and heavy loading in athletic performance.

Stress Relaxation Test

StrideGUARD demonstrates the ability to gradually dissipate mechanical stress over time after being compressed or loaded.

This means the material can absorb and redistribute pressure instead of concentrating forces at a single point. During repetitive motion or prolonged loading, this stress-relaxing behavior helps reduce peak mechanical strain on surrounding tissues while maintaining cushioning.

From Material Science to Movement

StrideGUARD™ was developed around the physical demands placed on the equine musculoskeletal system. Its collagen-supported, glycosaminoglycan- rich matrix is designed to remain cohesive, respond under applied force, and provide structural cushioning within the treatment area.

Because the goal is not simply to change what is inside the joint. The goal is to support how the horse moves through every stride.

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